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Baclofen relieves pain and improves muscle movement. If you think that you might have especially blood clots, strokes, kidney disease and epilepsy. Baclofen treatment can only help relax the muscles, diarrhea, headache, drowsiness, headaches, nausea, and weakness. Baclofen is available in tablet, oral liquid and injection form. Baclofen is the generic name for the anti-spastic medication Lioresal, which can lead to heavy sedation. You might have overdosed on Lioresal, you need to get emergency medical attention. People with certain types of bladder problems, history of seizures, psychiatric disorders, stomach ulcers, or liver problems should use Baclofen with caution.